One of the most common questions I get asked when self-publishing authors are looking at their book publishing options is about Lightning Source. LSI are one of the major Print-on-Demand digital printers in the world with centers in the US and UK. They not only offer print services but also book fulfillment services for publishers. Though they don't scream it from the roof-tops, authors can also set up an account with them and utilize their services.
Selfpublishingreview.com have a very helpful article on how an author goes about setting up an account with them here.
If you want to self-publish your book by taking a hands on approach, have some design skills, your own small imprint and block of ISBN's, and your are prepared to take on all the marketing that comes with properly self-publishing a book, then you really cannot go wrong with LSI.